Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2)
✍ Scribed by Rahner, Nils; Steinke, Verena; Schlegelberger, Brigitte; Olschwang, Sylviane; Eisinger, François; Hutter, Pierre
- Book ID
- 109849100
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 149 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1018-4813
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mutations in DNA repair genes have previously been identified as causative factors for hereditary nonpolyposis colon cancer (HNPCC). Recent evidence also supports an association between DNA sequence variation in these genes and sporadic colorectal carcinoma (CRC). Genetic investigation
## Abstract Epigenetic silencing of the O^6^‐methylguanine‐DNA methyltransferase (__MGMT__) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methyl
## Abstract A systematic search by Southern blot analysis in a cohort of 439 hereditary nonpolyposis colorectal cancer (HNPCC) families for genomic rearrangements in the main mismatch repair (MMR) genes, namely, __MSH2__, __MLH1__, __MSH6__, and __PMS2__, identified 48 genomic rearrangements causat