Clinical traits of LRRK2-associated Parkinson's disease in Ireland: A link between familial and idiopathic PD
โ Scribed by David Gosal; Owen A. Ross; Joe Wiley; G. Brent Irvine; Janet A. Johnston; Mathias Toft; Ignacio F. Mata; Jennifer Kachergus; Mary Hulihan; Julie P. Taylor; Sarah J. Lincoln; Matthew J. Farrer; Timothy Lynch; J. Mark Gibson
- Book ID
- 116820087
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 133 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Idiopathic Parkinson's disease (PD) can be subdivided by its patterns of motor symptoms into tremorโdominant (TDT), akineticโrigid (ART), and mixed type (MT). Our objective was to determine whether age at onset and family history are different in these three types. In total, 366 patient
## Abstract The G2019S mutation in the __LRRK2__ gene is reportedly a common cause of familial Parkinson's disease (PD) and may also have a significant role in nonfamilial PD. The objective of this study was to assess mutation carrier frequency in PD patients from movement disorder clinics in the U