## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucine‐rich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester
LRRK2mutation in familial Parkinson’s disease in a Taiwanese population: clinical, PET, and functional studies
✍ Scribed by Chin-Hsien Lin; Kai-Yuan Tzen; Chin-Yi Yu; Chun-Hwei Tai; Matthew J. Farrer; Ruey-Meei Wu
- Publisher
- BioMed Central
- Year
- 2008
- Tongue
- English
- Weight
- 272 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1021-7770
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## Abstract Mutations in the leucine‐rich repeat kinase 2 (__LRRK2__) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at cod
## Abstract Mutations in the __Leucine‐Rich Repeat Kinase 2__ (__LRRK2__) gene are the most frequent known cause of Parkinson's disease (PD), but their prevalence varies markedly between populations. Here we studied the frequency and associated phenotype of four recurrent __LRRK2__ mutations (R1441
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