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Clinical studies of β-thioguanine deoxyriboside alone and in combination with arabinosyl cytosine

✍ Scribed by Bodey, Gerald P. ;McCredie, Kenneth B. ;Whitecar, John P. ;Freireich, Emil J.

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
375 KB
Volume
2
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

β‐thioguanine deoxyriboside (βTGdR) is a purine nucleoside derivative which was studied alone or in combination with arabinosyl cytosine (Ara‐C) in patients with solid tumors and acute leukemia. No significant responses were observed in 22 patients with solid tumors. The response rate with βTGdR alone in acute leukemia was 26% and in combination with Ara‐C was 24%. Responses were generally of short duration. Toxicity included myelosuppression, nausea, stomatitis, hyperpigmentation, photosensitivity, and liver function abnormalities.

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