𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of mepindolol administered alone and in combination with hydrochlorothiazide—a bioequivalence study

✍ Scribed by W. Krause; Chr. Lennert

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
306 KB
Volume
4
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

The bioavailability and pharmacokinetics of 10 mg of mepindolol sulphate and of 25 mg df hydrochlorothiazide were compared in a cross-over design in five healthy volunteers after the administration of either the single drugs (Corindolan@ and Esidrix@) or in combination (Tenesor@).

Maximum concentrations of mepindolol in the plasma of 25 ngml-' were achieved 1.6 h after both treatments and the half-life of disposition was calculated to be 4-5 h, being somewhat longer after the combination tablet. The amount of hydrochlorothiazide renally eliminated up to 48 h after drug intake was about 60 per cent of the dose. The half-life of renal excretion was 3 h. The two formulations of mepindolol sulphate and hydrochlorothiazide proved to be bioequivalent with a tendency to better mepindolol bioavailability in the combination form.

📜 SIMILAR VOLUMES

Steady-state pharmacokinetics of diltiaz
Steady-state pharmacokinetics of diltiazem and hydrochlorothiazide administered alone and in combination
✍ Scott J. Weir; Dan C. Dimmitt; Robert C. Lanman; M. Bruce Morrill; Dennis H. Gei 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 2 views

Diltiazem and hydrochlorothiazide are widely used to treat cardiovascular disease, often in combination. The purpose of this investigation was to determine whether a drug -drug pharmacokinetic interaction exists between diltiazem and hydrochlorothiazide. In a randomized, crossover, open study, multi

Pharmacokinetic comparison of a combinat
Pharmacokinetic comparison of a combination tablet of enalapril and hydrochlorothiazide with enalapril and hydrochlorothiazide tablets administered together and separately
✍ L. G. Howes; E. L. Conway; P. A. Phillips; J. Broadbear; O. H. Drummer; W. J. Lo 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 401 KB 👁 1 views

Enalapril and hydrochlorothiazide (HCT) are established single agent treatments for mild hypertension and cardiac failure and are a potent combination in more severe or resistant cases. We have compared the pharmacokinetics of enalaprilat (the active metabolite of enalapril) and HCT in a four-way co

Pharmacokinetics of diltiazem and propra
Pharmacokinetics of diltiazem and propranolol when administered alone and in combination
✍ Dan C. Dimmitt; Dale K. Yu; Alfred T. Elvin; Dennis H. Giesing; Robert C. Lanman 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 1 views

Multiple oral doses of diltiazem (DTZ) and propranolol (PPL, 60 mg every 8 h daily for 13 doses) were administered to 14 healthy volunteers alone and in combination on three separate occasions. Serial blood samples were collected up to 24 h after dose 13 on day 5 to determine possible pharmacokineti

A study of the pharmacokinetics and phar
A study of the pharmacokinetics and pharmacodynamics of nifedipine in combination with atenolol
✍ T. J. Fitzsimons; S. C. Norris; H. K. Adam; J. Ryan; J. McAinsh 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB 👁 2 views

This double-blind randomized, crossover study was undertaken to determine the pharmacokinetic properties of nifedipine retard and atenolol when given separately, as a free or a fixed combination, compared with placebo in 15 healthy male volunteers. There was no difference between the three atenolol

Pharmacokinetics of dibenzylamine admini
Pharmacokinetics of dibenzylamine administered in a sustained drug delivery system with cefazolin
✍ M. B. Calvo; J. L. Pedraz; A. Dominguez-Gil 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB 👁 1 views

## Abstract The pharmacokinetics of dibenzylamine administered in a sustained drug delivery system with cefazolin was studied after i.m. administration of a dose of 1250 mg to healthy volunteers. The serum and urine levels of dibenzylamine were determined by a GLC technique using a specific nitroge