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Clinical significance of large rearrangements in BRCA1 and BRCA2

✍ Scribed by Thaddeus Judkins; Eric Rosenthal; Christopher Arnell; Lynn Anne Burbidge; Wade Geary; Toby Barrus; Jeremy Schoenberger; Jeffrey Trost; Richard J. Wenstrup; Benjamin B. Roa

Book ID
112067170
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
837 KB
Volume
118
Category
Article
ISSN
0008-543X

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Genomic rearrangements in the BRCA1 and
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✍ Sylvie Mazoyer πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 151 KB πŸ‘ 1 views

## Communicated by Richard Wooster Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer. BRCA1 and BRCA2 are 83 and 86 kb long, with coding sequences of 5.7 and 10.2 kb, scattered over 22 and 26 coding exons, respectively. The large majority of the alterations ident