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Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma

✍ Scribed by Yi-Fen Wang; Shyue-Yih Chang; Shyh-Kuan Tai; Wing-Yin Li; Liang-Shun Wang

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 501 KB
Volume: 24
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.10145

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✦ Synopsis

Background:

Recent studies showed that interleukin-6 (il-6) played a role in tumor development. however, available information about the prognostic significance of il-6 and il-6 receptors (il-6r) for oral squamous cell carcinoma (oscc) is limited.

Methods:

Eighty-six patients with oscc were enrolled. immunohistochemical staining was used to determine il-6r expression and in-situ hybridization for il-6 mrna transcripts in surgical specimens. clinicopathologic correlation was evaluated by chi-square test and survival by log rank test.

Results:

Expression rates of il-6r and il-6 mrna transcripts in tumor specimens were 73.3% and 54.7%, much higher than those in nontumor mucosa (p <.001). il-6r overexpression was associated with larger tumors and more advanced histologic grade (p <.05). the presence of il-6 mrna transcripts was inversely correlated with distant metastasis, lymph node involvement, and second primary scc (p <.05) and predicted better survival (p =.007).

Conclusions:

Il-6-il-6r coexpression was rather high in oscc, and il-6 mrna transcript expression might influence patient survival. the biologic role of il-6-il-6r coexpression in oscc needs additional investigation.

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