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Immunohistochemical expression of interleukin-4, -6, -8, and -12 in inflammatory cells in surrounding invasive front of oral squamous cell carcinoma

✍ Scribed by Marcos Vinícius Macedo de Oliveira; Carlos Alberto de Carvalho Fraga; Ricardo Santiago Gomez; Alfredo Maurício Batista D. Paula

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 697 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21121

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Cytokines play important roles in the diverse interactions between tumor microenvironment and malignant cells. This study evaluated the association of interleukin (IL)‐4, ‐6, ‐8, and ‐12 expressions and clinicopathologic parameters of 35 primary oral squamous cell carcinomas (OSCCs).

Methods

Patients were staged according to the TNM clinical staging. Malignancy grading of invasive front was evaluated in hematoxylin‐eosin (H&E)‐stained slides. Immunohistochemical technique was performed on frozen tissue sections. Association between clinicopathologic parameters and IL expression were analyzed using nonparametric Kruskal‐Wallis (α = 0,05) and Mann‐Whitney U tests, with Bonferroni correction. Correlations between interleukins were analyzed by the Spearman coefficient.

Results

Expression of ILs was verified in all samples; however, this finding was not related to clinicopathologic parameters. It was not the observed correlation between ILs.

Conclusions

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