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Clinical significance of 8q24/c-MYC translocation in diffuse large B-cell lymphoma

โœ Scribed by Nozomi Niitsu; Masataka Okamoto; Ikuo Miura; Masami Hirano

Book ID
108586371
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
201 KB
Volume
100
Category
Article
ISSN
1347-9032

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## Abstract Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large Bโ€cell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed u

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The sequence of the exon I lintron I boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8; 14) (q24q32) and the other with t(8;22) (q24;q I I). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding