Clinical pharmacology of intermediate-dose oral methotrexate
โ Scribed by D. K. Smith; G. A. Omura; F. Ostroy
- Book ID
- 112285964
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 399 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
The oral bioavailability of methotrexate is variable and may be dose-dependent. The absorption of 'interval' oral methotrexate, which is given between cycles of chemotherapy, is unknown. The bioavailability of oral methotrexate has been studied in eight patients, acting as their own controls, to ass
## Abstract Methotrexate (MTX), a potent folate antagonist by virtue of its ability to inhibit the enzyme dihydrofolate reductase [1], continues to be a useful cancer chemotherapeutic agent [2]. Information not only on its mechanism of action, but also its pharmacology has led to improved dosage sc
The relationship between salivary methotrexate (MTX) concentration and severity of oral mucositis after administration of MTX was investigated in six children with acute lymphoblastic leukemia. They received two administrations of MTX at 500 mgm' with one third given bolusly and the remainder by 24-