Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT
β¦ LIBER β¦
Clinical pharmacology of oral intermediate-dose methotrexate with or without probenecid
β Scribed by Michael B. Lilly; George A. Omura
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 259 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0344-5704
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## Background: This study was undertaken to determine whether the use of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin as first-line therapy increases the proportion of major responders and overall survival in patients with unresectable or metastatic tra