𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical pharmacology of methotrexate

✍ Scribed by Bertino, J. R.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
746 KB
Volume
10
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Methotrexate (MTX), a potent folate antagonist by virtue of its ability to inhibit the enzyme dihydrofolate reductase [1], continues to be a useful cancer chemotherapeutic agent [2]. Information not only on its mechanism of action, but also its pharmacology has led to improved dosage schedules of this drug alone and in combination. The use of high (gm) doses of MTX followed by leucovorin β€œrescue” has required close attention to the blood levels of this drug and has stimulated further studies of its clinical pharmacology, especially of high‐dose regimens.

This review summarizes the present status of the clinical pharmacology of MTX.

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