Clinical perspectives of bispecific antibodies in cancer
β Scribed by G. C. de Gast; J. G. J. van de Winkel; Bert E. J. E. G. Bast
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 126 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Abbreviations bsAb bispecific antibody
Bispecific antibodies (bsAbs) directed to tumor-associated antigens and to receptors mediating T-cell activation, such as the TCR/CD3 complex and the co-stimulatory CD28 molecule, are capable of activating T cells at the surface of tumor cells, resulting in tumor-cell killing. Here we report the pre
A bispecific monoclonal antibody (BsMAb) recognising carcinoembryonic antigen (CEA) and doxorubicin (Dox) was used in colorimetric microcytotoxicity assays with 3 human colon cancer cell lines (COLO320DM, SKCO1 and LS174T) showing no, high or medium CEA expression, respectively. The IC50 values for