Clinical implications of DNA methylation in hepatocellular carcinoma
β Scribed by Eric L. Sceusi; David S. Loose; Curtis J. Wray
- Book ID
- 111221188
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 441 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1365-182X
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## Abstract Abberrant DNA methylation is one of the hallmarks of cancerogenesis. Our study aims to delineate differential DNA methylation in cirrhosis and hepatic cancerogenesis. Patterns of methylation of 27,578 individual CpG loci in 12 hepatocellular carcinomas (HCCs), 15 cirrhotic controls and
The assessment of biological markers as potential indicators of disease aggressiveness is still an open problem in hepatocellular carcinoma. Cell proliferation and extracellular matrix (ECM)-associated antigens and tumor-cell products can be associated with clinical aggressiveness in this tumor type