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Detection of hepatitis B virus DNA in hepatocellular carcinoma: methylation of integrated viral DNA

✍ Scribed by Chen Jen-Yang; Hsu Hey-Chi; Lee Chue-Shue; Chen Ding-Shinn; Arie J. Zuckerman; Tim J. Harrison

Book ID: 119114557
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 547 KB
Volume: 19
Category: Article
ISSN: 0166-0934
DOI: 10.1016/0166-0934(88)90020-1

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## Abstract Gene inactivation through DNA hypermethylation plays a pivotal role in carcinogenesis. This study aimed to profile aberrant DNA methylation in different stages of liver disease, namely noncirrhosis, cirrhosis and hepatocellular carcinoma (HCC), and also to clarify the influence of hepat