We describe the first clinical application of T-cell-recruiting bispecific antibodies directly into the tumor without the need to preactivate the effector cells. In a Phase I clinical trial, 10 patients with low-grade B-cell lymphoma were treated by a single locoregional injection of CD3ุCD19 bispec
โฆ LIBER โฆ
Clinical Experience with CD3 X CD19 Bispecific Antibodies in Patients with B Cell Malignancies
โ Scribed by DE GAST, GIJSBERT C.; VAN HOUTEN, ANJA A.; HAAGEN, INEZ-ANNE; KLEIN, SIGRID; DE WEGER, ROEL A.; VAN DIJK, ANET; PHILLIPS, JENNY; CLARK, MIKE; BAST, BERT J.E.G.
- Book ID
- 125543472
- Publisher
- Mary Ann Liebert
- Year
- 1995
- Tongue
- English
- Weight
- 676 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1061-6128
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## Abstract To develop an effective antitumor immunotherapy for Bโlineage nonโHodgkin's lymphoma, we constructed a tetravalent tandem diabody (tanDb) specific for both human CD19 (Bโcell marker) and CD3 (Tโcell antigen). Here, we report the effective killing of malignant primary B cells from patien