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CD8 T cell activation after intravenous administration of CD3×CD19 bispecific antibody in patients with non-Hodgkin lymphoma

✍ Scribed by Gijsbert C. de Gast; Inez-Anne Haagen; Anja A. van Houten; Sigrid C. Klein; Ashley J. Duits; Roel A. de Weger; Thea M. Vroom; Mike R. Clark; Jenny Phillips; Anette J. G. van Dijk; Wim B. M. de Lau; Bert J. E. G. Bast

Book ID
105229599
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
710 KB
Volume
40
Category
Article
ISSN
0340-7004

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✍ Uwe Reusch; Fabrice Le Gall; Manfred Hensel; Gerhard Moldenhauer; Anthony D. Ho; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 284 KB

## Abstract To develop an effective antitumor immunotherapy for B‐lineage non‐Hodgkin's lymphoma, we constructed a tetravalent tandem diabody (tanDb) specific for both human CD19 (B‐cell marker) and CD3 (T‐cell antigen). Here, we report the effective killing of malignant primary B cells from patien