We describe the first clinical application of T-cell-recruiting bispecific antibodies directly into the tumor without the need to preactivate the effector cells. In a Phase I clinical trial, 10 patients with low-grade B-cell lymphoma were treated by a single locoregional injection of CD3؋CD19 bispec
✦ LIBER ✦
Costimulation with agonistic anti-CD28 antibodies prevents T cell apoptosis and is required for efficient immunotherapy with CD3x19 bispecific antibodies in B cell lymphoma
✍ Scribed by P.T. Daniel; A. Kroidl; A. Pezzutto; G. Moldenhauer; B. Dörken
- Book ID
- 117665661
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 137 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
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