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Clinical and molecular features of mucosa-associated lymphoid tissue (MALT) lymphomas of salivary glands

✍ Scribed by Andrea Toso; Paolo Aluffi; Daniela Capello; Annarita Conconi; Gianluca Gaidano; Francesco Pia

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
100 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

To analyze clinical features and to discuss the modality of investigation and treatment of a series of mucosa‐associated lymphoid tissue (MALT) lymphomas. To investigate the prevalence of aberrant promoter methylation, responsible for gene inactivation, in a selected panel of genes potentially involved in the pathogenesis of B‐cell malignancies as O6‐methylguanine‐DNA methyltransferase (MGMT), p73, death‐associated protein kinase (DAP‐k).

Methods.

Nine patients with primary MALT lymphoma of the salivary glands were retrospectively reviewed. MGMT, p73, DAP‐k apoptotic pathways were tested.

Results.

Methylation of DAP‐k was common (5/8; 63%). Histological examination ensured diagnostic confirmation, whereas fine‐needle aspiration cytology was not definitively diagnostic.

Conclusion.

Histological assessment is the gold standard in the diagnosis of salivary gland lesions. Parotidectomy represents a safe and reliable diagnostic tool leading to a definite diagnosis of MALT lymphomas in all cases and curative without other treatment in early‐stage MALT lymphoma. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

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