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Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx

✍ Scribed by Romain E. Kania; Dana M. Hartl; Cécile Badoual; Christine Le Maignan; Daniel F. Brasnu

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
544 KB
Volume
27
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. Mucosa-associated lymphoid tissue (MALT) lymphoma is usually associated with a chronic inflammatory disease from which lymphoid tissue of MALT type arises as a prerequisite for lymphoma proliferation. No wellcharacterized chronic inflammatory process has been identified in the larynx.

Methods. We report a case of primary MALT lymphoma of the larynx associated with extraesophageal reflux, chronic laryngitis, and gastric Helicobacter pylori infection, raising the issue of its physiopathology and treatment.

Results. Treatment of this MALT lymphoma of the larynx consisted of complete surgical excision associated with omeprazole, amoxicillin, and clarithromycin. No evidence of disease was observed after 24 months of follow-up.

Conclusions. We may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H.

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