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Clinical and biological significance of CDK4 amplification in well- differentiated and dedifferentiated liposarcomas

✍ Scribed by A. Italiano; L. Bianchini; F. Keslair; N. Cardot; C. Mainguene; D. Ranchere-Vince; P. Terrier; A. Leroux; J.M. Coindre; F. Pedeutour

Book ID: 119598822
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 89 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)71593-3

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## Abstract The __MDM2__ and __CDK4__ genes are the main targets of chromosome 12 amplification in well‐differentiated and dedifferentiated liposarcomas. Nevertheless, around 10% of these tumors do not amplify __CDK4__. To find substitutive alterations of __CDK4__ amplification, we analyzed a large

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