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Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases

✍ Scribed by Sioletic, Stefano; Dal Cin, Paola; Fletcher, Christopher D M; Hornick, Jason L

Book ID
119834539
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
922 KB
Volume
62
Category
Article
ISSN
0309-0167

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## Abstract The __MDM2__ and __CDK4__ genes are the main targets of chromosome 12 amplification in well‐differentiated and dedifferentiated liposarcomas. Nevertheless, around 10% of these tumors do not amplify __CDK4__. To find substitutive alterations of __CDK4__ amplification, we analyzed a large