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HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon

✍ Scribed by Antoine Italiano; Laurence Bianchini; Frédérique Keslair; Stéphanie Bonnafous; Nathalie Cardot-Leccia; Jean-Michel Coindre; Jean-Marc Dumollard; Paul Hofman; Agnès Leroux; Claire Mainguené; Isabelle Peyrottes; Dominique Ranchere-Vince; Philippe Terrier; Albert Tran; Philippe Gual; Florence Pedeutour

Book ID
102273957
Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
426 KB
Volume
122
Category
Article
ISSN
0020-7136

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## Abstract The __MDM2__ and __CDK4__ genes are the main targets of chromosome 12 amplification in well‐differentiated and dedifferentiated liposarcomas. Nevertheless, around 10% of these tumors do not amplify __CDK4__. To find substitutive alterations of __CDK4__ amplification, we analyzed a large