Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide
β Scribed by WANG, S.S. ;WANG, B.S.H. ;HUGHES, J.L. ;LEOPOLD, E.J. ;WU, C.R. ;TAM, J.P.
- Book ID
- 115099327
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 484 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0367-8377
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Ammonium for-mate aided catalytic transfer hydrogenation has been employed in the cleavage, and concommitant deprotection, of the pentapeptide leucine enkephalin from the Merrifield peptide resin under ambient conditions of temperature and pressure in a neutral medium.
Oxytocin, a nonapeptide amide, was synthesized on a PEGA-resin using the Fmoc-tBu strategy. The sulfhydryl groups of the two cysteine residues were protected with trityl groups. Different oxidation reagents such as DMSO, 12 and thallium(III) trifluoroacetate mixed with TFA were evaluated in order to