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Cleavage of single amino acid residues from Merrifield resin with hydrogen chloride and hydrogen fluoride

✍ Scribed by Scotchler, J.; Lozier, R.; Robinson, Arthur Brouhard.

Book ID
127122882
Publisher
American Chemical Society
Year
1970
Tongue
English
Weight
307 KB
Volume
35
Category
Article
ISSN
0022-3263

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Synthetic Methods and Reactions. Part 106. Suppression of anchimerically assisted rearrangement products in the synthesis of Ξ±-fluorocarboxylic acids from Ξ±-amino acids with 48:52 (w/w) hydrogen fluoride/pyridine [1]
✍ George A. Olah; G. K. Surya Prakash; Yah Li Chao πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 German βš– 153 KB

## Abstract Anchimerically assisted rearrangement, observed in the fluorination of some α‐amino acids with 70 : 30 (w/w) hydrogen fluoride/pyridine (by weight) in the presence of NaNO~2~, is substantially or fully suppressed by using the less acidic reagent 48 : 52 (w/w) hydrogen fluoride/pyridine.