✦ LIBER ✦
Synthetic Methods and Reactions. Part 106. Suppression of anchimerically assisted rearrangement products in the synthesis of α-fluorocarboxylic acids from α-amino acids with 48:52 (w/w) hydrogen fluoride/pyridine [1]
✍ Scribed by George A. Olah; G. K. Surya Prakash; Yah Li Chao
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- German
- Weight
- 153 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Anchimerically assisted rearrangement, observed in the fluorination of some α‐amino acids with 70 : 30 (w/w) hydrogen fluoride/pyridine (by weight) in the presence of NaNO~2~, is substantially or fully suppressed by using the less acidic reagent 48 : 52 (w/w) hydrogen fluoride/pyridine.