A rapid non-acidolytic method for deprotection and removal of peptides from solid phase resins - applications of ammonium formate catalytic transfer hydrogenation

✍ Scribed by Mohmed K. Anwer; Arno F. Spatola

• Publisher: Elsevier Science
• Year: 1981
• Tongue: French
• Weight: 227 KB
• Volume: 22
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)82959-2

✦ Synopsis

Ammonium for-mate aided catalytic transfer hydrogenation has been employed in the cleavage, and concommitant deprotection, of the pentapeptide leucine enkephalin from the Merrifield peptide resin under ambient conditions of temperature and pressure in a neutral medium.