## Abstract The virologic determinants of progressive liver disease associated with hepatitis B virus (HBV) remain unclear. Previous investigations have associated HBV disease with specific mutations but this association may be confounded by HBV genotype, HLA haplotype of the infected individual or
Clearance of acute hepatitis B IS associated with mutations in B and CTL epitopes of the core protein and the highly conserved region of the polymerase
β Scribed by S.A. Whalley; D. Brown; R. Jacobs; G.J.M. Webster; R. Hallett; G.M. Dusheiko; C.G. Teo
- Book ID
- 119527279
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 135 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer
The involvement of precore stop codon 1896-A and base exchanges in the AT-rich region at positions 1762 and 1764 of the hepatitis B core promotor has been controversely discussed in adults with fulminant hepatitis B. Because no data are currently available on children, we analyzed the basic core pro