Lack of association between mutations in the core region of hepatitis B virus (HBV) and fulminant hepatitis B
โ Scribed by McNair, A.N.B.; Viaggi, P.; Smith, H.M.; Naoumov, N.V.; Williams, Roger
- Book ID
- 122406629
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 156 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0016-5085
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The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer
## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in