A variant of hepatitis B virus has been described recently in HBsAg+ Mediterranean patients who lack HBeAg and who have an unusual and severe form of chronic hepatitis. This variant is unable to produce HBeAg because of the presence of a novel translational stop codon at the end of the precore regio
Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan
โ Scribed by Kiyoshi Hasegawa; Jiakang Huang; Jack R. Wands; Hiroshi Obata; T.Jake Liang
- Book ID
- 113209538
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 492 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0042-6822
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๐ SIMILAR VOLUMES
A precore defective variant of hepatitis B virus has been indicated to cause fulminant hepatitis in various instances such as intrahospital outbreaks or motherto-child transmission of hepatitis B virus. To learn whether similar variants are involved in interspouse transmission, we analyzed three cas
## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in