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Clean synthesis of furo[3,4-e]pyrazolo[3,4-b]pyridine-5-one derivatives in aqueous media

✍ Scribed by Da-Qing Shi; Hao Yao


Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
69 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

magnified image A series of 4‐aryl‐3‐methyl‐1‐phenyl‐7__H__‐furo[3,4‐e]pyrazolo[3,4‐b]pyridine‐5‐ones were synthesized via the three‐component reaction of an aldehyde, 5‐amino‐3‐methyl‐1‐phenyl‐1__H__‐pyrazole and tetronic acid in aqueous media in the presence of triethylbenzylammonium chloride (TEBAC). This method has the advantages of easier work‐up, mild reaction conditions, high yields, and an environmentally benign procedure. J. Heterocyclic Chem., (2009).


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