Clean synthesis of furo[3,4-e]pyrazolo[3,4-b]pyridine-5-one derivatives in aqueous media
✍ Scribed by Da-Qing Shi; Hao Yao
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2009
- Tongue
- English
- Weight
- 69 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.224
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
magnified image A series of 4‐aryl‐3‐methyl‐1‐phenyl‐7__H__‐furo[3,4‐e]pyrazolo[3,4‐b]pyridine‐5‐ones were synthesized via the three‐component reaction of an aldehyde, 5‐amino‐3‐methyl‐1‐phenyl‐1__H__‐pyrazole and tetronic acid in aqueous media in the presence of triethylbenzylammonium chloride (TEBAC). This method has the advantages of easier work‐up, mild reaction conditions, high yields, and an environmentally benign procedure. J. Heterocyclic Chem., (2009).
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