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A facile synthesis of furo[3,4-e]pyrazolo[3,4-b]pyridine-5(7H)-one derivatives via three-component reaction in ionic liquid without any catalyst

✍ Scribed by Da-Qing Shi; Fang Yang; Sai-Nan Ni

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
204 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of furo[3,4‐e]pyrazolo[3,4‐b]pyridine‐5(7__H__)‐one and indeno[2,1‐e]pyrazolo[3,4‐b]pyridine‐5(1__H__)‐one derivatives were synthesized via the three‐component reaction of an aldehyde, 5‐aminopyrazole and either tetronic acid or 1,3‐indanedione in ionic liquid without any catalyst. The structures of the products have been established by spectroscopic data and further confirmed by X‐ray diffraction analysis. This method has the advantages of easier work‐up, mild reaction conditions, high yields and an environmentally benign procedure. J. Heterocyclic Chem., 46, 469 (2009).

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✍ Feng Shi; Shujiang Tu; Bo Jiang; Chunmei Li; Dianxiang Zhou; Qingqing Shao; Long 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 421 KB

## Abstract magnified image A series of furo[3,4‐__e__]pyrazolo[3,4‐__b__]pyridine analogues of podophylloxin were synthesized __via__ three‐component reactions of aldehydes, 3‐methyl‐1‐phenyl‐1__H__‐pyrazol‐5‐amine and tetronic acid in water under microwave irradiation without catalyst. This effi