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A green and efficient synthesis of furo[3,4-e]pyrazolo[3,4-b]-pyridine derivatives in water under microwave irradiation without catalyst

✍ Scribed by Feng Shi; Shujiang Tu; Bo Jiang; Chunmei Li; Dianxiang Zhou; Qingqing Shao; Longji Cao; Qian Wang; Jianfeng Zhou

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
421 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of furo[3,4‐e]pyrazolo[3,4‐b]pyridine analogues of podophylloxin were synthesized via three‐component reactions of aldehydes, 3‐methyl‐1‐phenyl‐1__H__‐pyrazol‐5‐amine and tetronic acid in water under microwave irradiation without catalyst. This efficient synthesis not only offers an economical and green synthetic strategy to this class of significant compounds but also enriches the investigations on microwave‐assisted synthesis in water.

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