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Classification of Drug Permeability with a Caco-2 Cell Monolayer Assay

โœ Scribed by Volpe, Donna A.; Faustino, Patrick J.; Ciavarella, Anthony B.; Asafu-Adjaye, Ebenezer B.; Ellison, Christopher D.; Yu, Lawrence X.; Hussain, Ajaz S.

Book ID
118036133
Publisher
Informa plc
Year
2007
Tongue
English
Weight
138 KB
Volume
24
Category
Article
ISSN
1060-1333

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Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2, cultured on permeable supports, are commonly used to predict the absorption of orally administered drugs and other xenobiotics. This protocol describes our method for the cultivation, characterization and dete