Cationized gelatins, candidate absorption enhancers, were prepared by addition of ethylenediamine or spermine to gelatin and the effects of the resulting ethylenediaminated gelatin (EG) and sperminated gelatin (SG) on the paracellular transport of 5(6)-carboxyfluorescein (CF), FITC-dextran-4 (FD4),
Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers
โ Scribed by Donna A. Volpe; Ebenezer B. Asafu-Adjaye; Christopher D. Ellison; Suresh Doddapaneni; Ramana S. Uppoor; Mansoor A. Khan
- Book ID
- 111767503
- Publisher
- American Association of Pharmaceutical Scientists
- Year
- 2008
- Tongue
- English
- Weight
- 96 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1550-7416
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Studying the permeability of compounds across a Caco-2 cell monolayer is an established in vitro model to screen for oral absorption and to evaluate the mechanism of transport. This assay can also be used to evaluate compounds as potential P-glycoprotein substrates and/or inhibitors. The traditional
The Biopharmaceutics Classiยฎcation System (BCS) allows waivers of in vivo bioequivalence for rapidly dissolving immediate-release (IR) formulations of drugs with high solubility and high permeability. One potential issue in possibly extending BCS biowaivers to low-permeability drugs is the potential