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Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

✍ Scribed by Mohan Singh, Parvesh Chaudhry, Francois Fabi, Eric Asselin


Book ID
120679996
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
363 KB
Volume
13
Category
Article
ISSN
1471-2407

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## Abstract Aurora‐A is frequently altered in epithelial malignancies. Overexpressing Aurora‐A induces centrosome amplification and G2/M cell cycle progression. We have previously shown elevated level of Aurora‐A in ovarian cancer and activation of telomerase by Aurora‐A in human mammary and ovaria