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Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner

✍ Scribed by Xiaojuan Yan; Michael Fraser; Qing Qiu; Benjamin K. Tsang


Book ID
113960436
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
452 KB
Volume
102
Category
Article
ISSN
0090-8258

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## Abstract Aurora‐A is frequently altered in epithelial malignancies. Overexpressing Aurora‐A induces centrosome amplification and G2/M cell cycle progression. We have previously shown elevated level of Aurora‐A in ovarian cancer and activation of telomerase by Aurora‐A in human mammary and ovaria