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Inactivation of p53 in a Human Ovarian Cancer Cell Line Increases the Sensitivity to Paclitaxel by Inducing G2/M Arrest and Apoptosis

✍ Scribed by Faina Vikhanskaya; Sara Vignati; Patrizia Beccaglia; Cristina Ottoboni; Patrizia Russo; Maurizio D'Incalci; Massimo Broggini


Book ID
115602944
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
292 KB
Volume
241
Category
Article
ISSN
0014-4827

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Inactivation of p53 in normal human cell
✍ Jocelyn CΓ©raline; GaΓ«l Deplanque; Brigitte Duclos; Jean-Marc Limacher; Amor Hajr πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 206 KB πŸ‘ 2 views

p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh