Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial
✍ Scribed by Vermorken, Jan B; Stöhlmacher-Williams, Jan; Davidenko, Irina; Licitra, Lisa; Winquist, Eric; Villanueva, Cristian; Foa, Paolo; Rottey, Sylvie; Skladowski, Krzysztof; Tahara, Makoto; Pai, Vasant R; Faivre, Sandrine; Blajman, Cesar R; Forastiere, Arlene A; Stein, Brian N; Oliner, Kelly S; Pan, Zhiying; Bach, Bruce A
- Book ID
- 120502309
- Publisher
- The Lancet
- Year
- 2013
- Tongue
- English
- Weight
- 615 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1470-2045
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## Abstract ## Objective. We assessed the response rate and the toxicity of cisplatin plus vinorelbine in patients with this condition. ## Patients and Method. Forty‐two patients were included. Therapy consisted of cisplatin, 100 mg/m^2^ on day 1, and vinorelbine, 25 mg/m^2^ on days 1 and 8, giv
## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi