Weekly cisplatin paclitaxel and continuous infusion fluorouracil in patients with recurrent and/or metastatic head and neck squamous cell carcinoma: a phase II study
β Scribed by M. Schena; C. Barone; N. Birocco; D. Dongiovanni; G. Numico; I. Colantonio; O. Bertetto
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 207 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0344-5704
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## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi
## Abstract ## Objective. We assessed the response rate and the toxicity of cisplatin plus vinorelbine in patients with this condition. ## Patients and Method. Fortyβtwo patients were included. Therapy consisted of cisplatin, 100 mg/m^2^ on day 1, and vinorelbine, 25 mg/m^2^ on days 1 and 8, giv