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Circulating antibodies against c-MYC oncogene product in sera of colorectal cancer patients

✍ Scribed by Kamel Ben-Mahrez; Irène Sorokine; Dominique Thierry; Toshiyuki Kawasumi; Sunsuke Ishii; Remy Salmon; Masamichi Kohiyama

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
546 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

We developed a Western blot assay using purified human c-myc protein expressed in E. coli in order to look for circulating anti-c-myc antibodies in human sera. The presence of IgG antibodies against c-myc was observed in 25 out of 44 sera from patients with colorectal cancer diagnosed and treated at the Hdpital Curie in Paris, compared to the sera of 46 normal donors of which only 8 samples were positive (p = 0.001).

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