𝔖 Bobbio Scriptorium
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Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

✍ Scribed by L. V. Crawford; D. C. Pim; R. D. Bulbrook

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
658 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Antibodies reacting with the host protein p53 were found in the sera of patients with primary or secondary carcinoma of the breast. Fourteen out of the 155 sera from breast cancer patients tested were positive for anti‐p53 antibodies (9%) and no positives were detected among 164 control sera from normal women tested. The locations of the first metastasis in patients with positive sera were unusual, with more lung metastases and fewer bone metastases than expected. The detection of anti‐p53 antibodies indicates that p53 is altered in amount, type or presentation in breast tumors so that it becomes immunogenic.

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