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Cigarette sidestream smoke induces phosphorylated histone H2AX

✍ Scribed by Tatsushi Toyooka; Yuko Ibuki

Book ID: 116759599
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 656 KB
Volume: 676
Category: Article
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2009.03.002

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## Background In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on __Ser__139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as __ataxia telangiectasia__ mutated (ATM), ATM-and Rad-3 related (ATR) kinase, or by DNA dependent prot