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Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX

✍ Scribed by Tatsushi Toyooka; Go Ohnuki; Yuko Ibuki

Book ID: 116759394
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 709 KB
Volume: 650
Category: Article
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2007.11.002

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## Abstract ## Background The induction of DNA double‐strand breaks (DSBs) in chromatin triggers histone H2AX phosphorylation (on __Ser__‐139) by ATM‐, ATR‐, or DNA‐dependent protein kinases (DNA‐PK). Phosphorylated H2AX, denoted as γH2AX, can be detected immunocytochemically using an antibody tha