Coexposure to benzo[a]pyrene and UVA induces phosphorylation of histone H2AX
β Scribed by Tatsushi Toyooka; Yuko Ibuki
- Book ID
- 116466114
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 274 KB
- Volume
- 579
- Category
- Article
- ISSN
- 0014-5793
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## Abstract ## Background The induction of DNA doubleβstrand breaks (DSBs) in chromatin triggers histone H2AX phosphorylation (on __Ser__β139) by ATMβ, ATRβ, or DNAβdependent protein kinases (DNAβPK). Phosphorylated H2AX, denoted as Ξ³H2AX, can be detected immunocytochemically using an antibody tha
## Abstract The polycyclic aromatic hydrocarbons (PAHs) dibenzo[__a,l__]pyrene (DBP) and benzo[__a__]pyrene (BP) are environmental contaminants and potent carcinogens. DBP is several orders of magnitude more mutagenic/carcinogenic than BP. This can be ascribed to differences in DNA binding efficien