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Chronological and replicative lifespan of polyploid Saccharomyces cerevisiae (syn. S. pastorianus)

✍ Scribed by Dawn L Maskell; Alan I Kennedy; Jeff A Hodgson; Katherine A Smart

Book ID
104443545
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
252 KB
Volume
3
Category
Article
ISSN
1567-1356

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✦ Synopsis

Chronological lifespan may be defined as the result of accumulation of irreversible damage to intracellular components during extended stationary phase, compromising cellular integrity and leading to death and autolysis. In contrast, replicative lifespan relates to the number of divisions an individual cell has undertaken before entering a non-replicative state termed senescence, leading to cell death and autolysis. Both forms of lifespan have been considered to represent models of ageing in higher eukaryotes, yet the relation between chronologically and replicatively aged populations has not been investigated. In this study both forms of lifespan have been investigated in Saccharomyces cerevisiae (Syn. S. pastorianus) to establish the relationship between chronological and replicative ageing.

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## Abstract Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose fu