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The lipophilic antioxidants α-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae

✍ Scribed by Yuen Ting Lam; Roland Stocker; Ian W. Dawes


Book ID
113631111
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
692 KB
Volume
49
Category
Article
ISSN
0891-5849

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Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (Q 10 H 2 , 500 mg/kg BW/ day) of coenzyme Q 10 (CoQ 10 ). To unravel molecular mechanisms of these CoQ 10 effects, a genome-wide transcr