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Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo

✍ Scribed by Hayley S Ramshaw; Peter G Bardy; Melissa A Lee; Angel F Lopez


Book ID
114216919
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
177 KB
Volume
30
Category
Article
ISSN
0301-472X

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Recent molecular studies have revealed that the GM-CSF/RAS signaling pathway plays a central role in the pathogenesis of juvenile myelomonocytic leukemia (JMML). CFU-GM colony assay is an important test for GM-CSF hypersensitivity in patients with JMML, but requires specific skills. We established a