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Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia

✍ Scribed by Nobuhiro Nishio; Yoshiyuki Takahashi; Makito Tanaka; Yinyan Xu; Nao Yoshida; Hirotoshi Sakaguchi; Sayoko Doisaki; Asahito Hama; Hideki Muramatsu; Akira Shimada; Seiji Kojima

Book ID: 113773421
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 506 KB
Volume: 35
Category: Article
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2011.04.014

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Recent molecular studies have revealed that the GM-CSF/RAS signaling pathway plays a central role in the pathogenesis of juvenile myelomonocytic leukemia (JMML). CFU-GM colony assay is an important test for GM-CSF hypersensitivity in patients with JMML, but requires specific skills. We established a