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Chronic myeloid leukemia associated with pure red cell aplasia and terminating in promyelocytic transformation

✍ Scribed by Aleksandar Mijovic; Zoran Rolovic; Angelina Novak; Lidija Biljanovic-Paunovic; Dragica Tomin

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 217 KB
Volume: 31
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830310211

No coin nor oath required. For personal study only.

✦ Synopsis

After intermittent treatment with busulphan over a 7-year period for chronic myeloid leukemia (CML) in chronic phase, a 39-year-old female developed leukocytosis in association with pure red cell aplasia (PRCA). Bone marrow examination confirmed erythroid aplasia, and culture revealed a total absence of erythroid progenitor cells. The patient then was treated with azathioprine, corticosteroids, cyclophosphamide, plasma exchange, and cyclosporin A, but she remained erythroblastopenic and transfusion dependent for more than a year, at which time a promyelocytic transformation supervened. The authors propose that this sequence of events, hitherto unreported, is a manifestation of the multistep progression of CML.

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